PHASE I STUDY EVALUATING THE TREATMENT OF PATIENTS WITH HEPATOCELLULAR CARCINOMA (HCC) WITH CARBON ION RADIOTHERAPY: THE PROMETHEUS-01 TRIAL

Phase i study evaluating the treatment of patients with hepatocellular carcinoma (HCC) with carbon ion radiotherapy: The PROMETHEUS-01 trial

Abstract Background Treatment options for patients with advanced hepatocellular carcinoma (HCC) are often limited.In most cases, they are not amenable to local therapies including surgery or radiofrequency ablation.The multi-kinase inhibitor sorafenib has Carousel shown to increase overall survival in this patient group for about 3 months.Radiation

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Amino acid deprivation triggers a novel GCN2-independent response leading to the transcriptional reactivation of non-native DNA sequences.

In a variety of species, reduced food intake, and in particular protein or amino acid (AA) restriction, extends lifespan and healthspan.However, the underlying epigenetic and/or transcriptional latigos mechanisms are largely unknown, and dissection of specific pathways in cultured cells may contribute to filling this gap.We have previously shown th

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THE SEXUALITY IN THE EYES OF THE STUDENTS GRADUATING IN NURSING

The sexuality is a theme registered with a great frequency nowadays, but, paradoxically, difficult to approach, due to its inherent cultural and philosophical aspects.The health environment is not an exception, since the concept of sexuality in it also emerges rich in norms and interdictions.Conscious of this reality and experiencing this reality,

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